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Editor Spotlight
Sara Wickström directs the department of Cell and Tissue Dynamics at the Max Planck Institute of Molecular Biomedicine in Münster, Germany. She received her MD in 2001 and PhD in 2004 from the University of Helsinki. After postdoctoral training she joined the Max Planck Institute for Biology of Ageing in Cologne, Germany as Group Leader in 2010. In 2018 her laboratory moved to the Helsinki Institute for Life Science at the University of Helsinki, Finland where she held a professorship in Cell and Developmental Biology. In 2022 Wickström was appointed as Director of the Max Planck Institute for Molecular Biomedicine. She received an ERC Consolidator grant in 2018 and in 2020 was elected to be member of EMBO. Website: www.mpi-muenster.mpg.de/660820/wickstrom Meet the Team • Alex Gould, PhD (Francis Crick Institute), www.crick.ac.uk/research/labs/alex-gould
• Nicolas Rivron, PhD, Eng, MSc ((Austrian Academy of Sciences’ Institute of Molecular Biotechnology (IMBA)),www.oeaw.ac.at/imba/research/nicolas-rivron Publish With Us Our editorial team is excited to evaluate papers that study the genetic, epigenetic, biochemical and biomechanical events that underpin stem cell behavior and dynamics. This includes studies using mouse models, various cell culture systems and organoids. We are interested in studies that challenge existing dogma and provide paradigm-shifting insight into mechanisms of stem cell fate selection and regulation of differentiation, as well as their roles in tissue development, homeostasis, regeneration and disease. Submit your paper today for publication consideration in Science Advances.Learn more on how to submit a manuscript today, here. For further inquiries, please contact the Science Advances Editorial Office at ScienceAdvancesEditorial@aaas.org. About Science Advances Science Advances is the gold, open-access, multidisciplinary expansion of the journal Science. Led by a large board of active, prominent researchers, Science Advances publishes work across all areas of science, highlighting both broad impact and disciplinary-specific breakthroughs. Our editors strive to provide authors with fair, fast, expert peer review and readers with free access to ground-breaking advancements in science across all disciplines. As a high caliber, open-access journal, Science Advances is committed to the mission of its publisher, the American Association for the Advancement of Science (AAAS), the not-for-profit organization dedicated to advancing science, engineering, and innovation throughout the world for the benefit of all people. Learn more>> Like us on Facebook @ScienceAdvances | Follow us on Twitter @ScienceAdvances |
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Sara Wickström, MD/PhD is an internationally renowned researcher in the field of stem cells and mechanobiology. Her research aims to understand how mammalian epithelial tissues are generated and maintained. In particular, she examines how mechanical forces and cellular interactions integrate single stem cell behaviors to pattern these structurally extremely robust yet dynamic tissues. Specifically, the Wickström lab combines mouse genetics and human patient material with scale-bridging technologies from nanoscale atomic force microscopy and next generation sequencing to whole organism live imaging and in silico modeling. The research is highly interdisciplinary and involves collaborations with mathematicians, physicists and clinical oncologists. Recent work from Wickström has uncovered how tissue-scale forces allow coordination of proliferation and differentiation events to regulate tissue morphogenesis and size. Furthermore, her laboratory has discovered how extrinsic forces generated by the tissue impact chromatin structure and epigenetic gene silencing, thereby controlling genome integrity, the transcriptional state and lineage commitment of stem cells.
