This month in BioMed Roundup:     Holubcová et al. used more than 100 live human oocytes to reveal details of human meiosis and major contributors of chromosome segregation defects. Jump to: Neuroscience Biochemistry Cell Biology Medicine Immunology Molecular Biology Physiology Psychology Development               NEUROSCIENCE     C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits (5 June 2015) J. Chew et al. A mouse model mimics the pathological and behavioral abnormalities seen in certain amyotrophic lateral sclerosis or frontotemporal dementia patients. Cortical information flow during flexible sensorimotor decisions (19 June 2015) Markus Siegel, Timothy J. Buschman, and Earl K. Miller A dynamic network of cortical areas processing similar information but to different degrees is explored. A parvalbumin-positive excitatory visual pathway to trigger fear responses in mice (26 June 2015) C. Shang et al. A newly identified subcortical pathway links visual inputs to the fear center of the brain.         BIOCHEMSITRY     2.2 Å RESOLUTION CRYO-EM STRUCTURE OF ?-GALACTOSIDASE IN COMPLEX WITH A CELL-PERMEANT INHIBITOR (5 June 2015) A. Bartesaghi et al. ADVANCES IN ELECTRON MICROSCOPY ALLOW PROTEIN STRUCTURE DETERMINATION AT RESOLUTIONS USEFUL IN DRUG DISCOVERY STRUCTURAL BASIS FOR NUCLEOTIDE EXCHANGE IN HETEROTRIMERIC (19 June 2015) R. O. Dror et al. ATOMIC-LEVEL SIMULATIONS SHOW HOW G PROTEIN–COUPLED RECEPTORS TRIGGER G PROTEIN SIGNALING.. DESIGN OF ORDERED TWO-DIMENSIONAL ARRAYS MEDIATED BY NONCOVALENT PROTEIN-PROTEIN INTERFACES (19 June 2015) S. Gonen et al. A COMPUTATIONAL APPROACH ALLOWS THE DESIGN OF PROTEINS THAT SELF-ASSEMBLE INTO TWO-DIMENSIONAL LATTICES. A CAS9–GUIDE RNA COMPLEX PREORGANIZED FOR TARGET DNA RECOGNITION (26 June 2015) F. Jiang et al. THE GUIDE RNA IN THE CRISPR-CAS IMMUNE/EDITING SYSTEM IS POISED TO INITIATE RECOGNITION OF TARGET DNA.     CELL BIOLOGY     Error-prone chromosome-mediated spindle assembly favors chromosome segregation defects in human oocytes (5 June 2015) Z. Holubcová et al. Studies using isolated human oocytes reveal details of human meiosis. Reversible centriole depletion with an inhibitor of Polo-like kinase 4 (5 June 2015) Y. L. Wong et al. An "organelle knockout" strategy reveals that cancer cells but not normal cells can divide in the absence of centrosomes. See related Perspective Kinetochore attachment sensed by competitive Mps1 and microtubule binding to Ndc80C (12 June 2015) Zhejian Ji, Haishan Gao, and Hongtao Yu Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling. Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling (12 June 2015) Y. Hiruma et al. A sensor for the mitotic spindle assembly checkpoint is revealed. Endocytic sites mature by continuous bending and remodeling of the clathrin coat (19 June 2015) O. Avinoam et al. The clathrin lattice appears to be remodeled during coated vesicle budding.     MEDICINE     A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging (5 June 2015) C Chang et al. Stabilization of heterochromatin by WRN protein safeguards human mesenchymal stem cells from aging. See related Perspective Phthalimide conjugation as a strategy for in vivo target protein degradation (19 June 2015) G. E. Winter et al. A chemical strategy that leads to selective destruction of proteins of interest may be a valuable tool for drug development.     IMMUNOLOGY     Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity (12 June 2015) R. G. Gaudet et al. Eukaryotic cells use the host protein TIFA to sense the monosaccharide HBP, derived from Gram-negative bacteria See related Perspective     MOLECULAR BIOLOGY     EPIGENETIC SILENCING BY THE HUSH COMPLEX MEDIATES POSITION-EFFECT VARIEGATION IN HUMAN CELLS (26 June 2015) I. A. Tchasovnikarova et al. A HAPLOID GENETIC SCREEN IN HUMAN CELLS IDENTIFIES AN EPIGENETIC SILENCING COMPLEX THAT REGULATES HETEROCHROMATIN FORMATION. See related Perspective FACTOR-DEPENDENT PROCESSIVITY IN HUMAN EIF4A DEAD-BOX HELICASE (26 June 2015) C. Garcia-Garcia et al. A COMPLEX OF THREE PROTEIN TRANSLATION INITIATION FACTORS IS ABLE TO UNWIND MESSENGER RNA CONTINUOUSLY AND DIRECTIONALLY.     PHYSIOLOGY     DISCRETE FUNCTIONS OF NUCLEAR RECEPTOR REV-ERB? COUPLE METABOLISM TO THE CLOCK (26 June 2015) Y. Zhang et al. A TRANSCRIPTION FACTOR THAT CONTROLS BOTH CIRCADIAN RHYTHMS AND METABOLISM DOES SO THROUGH DIFFERENT GENOMIC MECHANISMS     PSYCHOLOGY     REGULATION OF BREATHING BY CO2 REQUIRES THE PROTON-ACTIVATED RECEPTOR GPR4 IN RETROTRAPEZOID NUCLEUS NEURONS (12 June 2015) N. N. Kumar et al. A G protein–coupled receptor in the brain controls respiration.     Development     A male-determining factor in the mosquito Aedes aegypti (12 June 2015) A. Brantleyet al. An M-locus gene is necessary and sufficient for male development in the mosquito that transmits dengue and yellow fever. Recruitment of RNA polymerase II by the pioneer transcription factor PHA-4 (19 June 2015) H. -T. Hsuet al. A transcription factor involved in cell-fate changes also facilitates chromatin opening.