Science Signaling Table of Contents

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Science Signaling

Table of Contents

27 November 2012

Volume 5, Issue 252

With 13 new opportunities, find funding for research and training related to cell signaling. Funding Sources

In this week's issue:

Research Articles

REDOX SIGNALING Regulation of Phosphatidylinositol-5-Phosphate Signaling by Pin1 Determines Sensitivity to Oxidative Stress Willem-Jan Keune et al. Increasing the abundance of the phospholipid PtdIns5P protects cells from oxidative stress. IMMUNOLOGY Lack of the Phosphatase PTPN22 Increases Adhesion of Murine Regulatory T Cells to Improve Their Immunosuppressive Function Rebecca J. Brownlie et al. Loss of the phosphatase PTPN22 enhances the functions of both effector and regulatory T cells.

Perspectives

DEVELOPMENTAL BIOLOGY Remodeling a Tissue: Subtraction Adds Insight Jeffrey D. Axelrod Imaging, modeling, and genetics reveal the roles of an atypical myosin in morphogenesis.

Podcasts

IMMUNOLOGY Science Signaling Podcast: 27 November 2012 Rose Zamoyska and Annalisa M. VanHook A phosphatase implicated in autoiummunity modulates the activities of both effector and regulatory T cells.

Editors' Choice

IMMUNOLOGY Ceramide Keeps Mast Cells in Check John F. Foley A receptor that binds to extracellular ceramide inhibits mast cell activation and allergic responses in vivo. IMMUNOLOGY The Allergen in the Dust Wei Wong The bacterial protein flagellin can promote allergic asthma by activating Toll-like receptor 5. PLANT BIOLOGY Double Delivery During Plant Fertilization Pamela J. Hines The cysteine-rich proteins of Arabidopsis egg and central cells enable fusion with just one sperm each. IMMUNOLOGY Bcl10 Does Double Duty Annalisa M. VanHook A protein that promotes NF-κB signaling during the immune response is also required for phagocytosis independently of NF-κB. CANCER Help for Starving Cells Paula A. Kiberstis A metabolite is identified that may help cancer cells coordinate their mode of energy generation with nutrient conditions.

Errata

A Correction to the Presentation Titled: “Protein Complexes and Target Genes Identification by in Vivo Biotinylation: The STAT5 Paradigm” by E. Katsantoni A typographical error in the name of a medical condition described on Slide 9 is corrected.


Forum

Meeting Highlights Highlights from Understanding Signaling Pathways in Cancer Leslie K. Ferrarelli and Nancy R. Gough View Comments

Funding Sources

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