Science Translational Medicine Table of Contents

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Science Translational Medicine

Table of Contents

5 December 2012

Volume 4, Issue 163

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In this week's issue:

Research Articles

PARKINSON’S DISEASE α-Synuclein–Induced Down-Regulation of Nurr1 Disrupts GDNF Signaling in Nigral Dopamine Neurons Mickael Decressac et al. The trophic response of dopamine neurons to GDNF, mediated by the transcription factor Nurr1, protects them from α-synuclein–mediated toxicity. NEURODEGENERATIVE DISEASE Decreased Tonic Inhibition in Cerebellar Granule Cells Causes Motor Dysfunction in a Mouse Model of Angelman Syndrome Kiyoshi Egawa et al. Ube3a deficiency causes a decrease in cerebellar tonic inhibition by preventing degradation of GABA transporter 1 in a mouse model of Angelman syndrome. IMMUNOLOGY Overexpression of Methyl-CpG Binding Protein 2 Impairs T_H1 Responses Tianshu Yang et al. Duplication of the MECP2 gene in humans and mice results in immune dysregulation due in part to the suppression of IFN-γ production from T helper cells.

Focus

IMMUNE DYSFUNCTION The Goldilocks Effect Mark Boothby and Christopher L. Williams Modest overexpression of an epigenetic regulatory protein alters T helper cell differentiation and immune defects. REGULATORY SCIENCE Creating a Space for Innovative Device Development Michelle McMurry-Heath and Margaret A. Hamburg FDA announces a partnership—the Medical Device Innovation Consortium—to advance regulatory science in the medical technology arena.

Editors' Choice

IMMUNOLOGY A New Way for Natural Killers to Find Their “Missing-Self” Niroshana Anandasabapathy Noncanonical major histocompatibility complex class I may contribute to natural killer cell licensing. ALLERGY Driving a Wedge into Acute Allergic Responses Joel H. Collier A new strategy for stripping immunoglobulin E from mast cells has potential as a therapy for anaphylaxis-inducing allergic reactions. STEM CELLS Surprise After the Prize: Innate Immune Signaling Required for Pluripotency Matthias Nahrendorf Signaling through the Toll-like receptor TLR3 is necessary for generation of induced pluripotent stem cells AUTOIMMUNITY The Rise and Fall of an Immune Response Jagdeep S. Obhrai The same signals that initiate B cell–T cell interactions may be responsible for regulatory B cell differentiation. DIABETES Coffee Consumption: It Does a Body Good Marina Reznik Coffee and tea intake is associated with a lower risk of type 2 diabetes. ASTHMA Twin Towers, Twin Epidemics: Obesity and Asthma Amir A. Zeki Obesity hinders the clearance of dead inflammatory cells in asthmatic lungs and is associated with reduced glucocorticoid responsiveness and oxidative stress.

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